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November 1, 2025
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research article
High-throughput conjugation reveals strain specific recombination patterns enabling precise trait mapping in Escherichia coli
In this article, the authors develop a high-throughput conjugation method in E. coli and, using whole-genome sequencing, reveal strain-specific recombination patterns with fragment sizes from under 10 kb to over 1 Mb. This diversity enables kilobase-scale trait mapping and challenges the view that conjugation only transfers large DNA segments.
Image credit: pgen.1011636
Current Issue October 2025
10/27/2025
research article
TERT translocation to mitochondria: Exploring its role in mitochondrial homeostasis
Here, the authors show that TERT localizes within mitochondria under physiological conditions, independent of TERC. TERT binds mitochondrial DNA, influencing replication and transcription, and induces mitochondrial network fragmentation. These findings suggest that TERT regulates mitochondrial biogenesis and dynamics to maintain homeostasis and link its non-canonical functions to cellular states and disease.
Image credit: pgen.1011923
10/27/2025
research article
The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration
Through an RNAi screen in the Drosophila midgut, the authors identify the epigenetic factor Zrf1 as a key regulator of intestinal stem cell proliferation. Functional analyses show that Zrf1 integrates signals from multiple pathways and interacts with components of the RNA-induced silencing complex (RISC), suggesting it acts as a chromatin regulator essential for maintaining stem cell proliferation.
Image credit: pgen.1011910
10/31/2025
research article
The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae
Here, the authors present an isodecoder-level map of tRNA modifications in Vibrio cholerae, generated using chemical sequencing of wild-type and deletion strains. This first validated genome-wide map of tRNA modifications in V. cholerae provides a reference for studying RNA modification and translation in this pathogen.
Image credit: pgen.1011937
10/31/2025
research article
METTL3 facilitates the translation of CircSIK2 during chicken myogenesis in an m6A dependent manner
Using sequencing, ribosome profiling and mass spectrometry, the authors identify circular RNAs translated during chicken myogenesis. They show that circSIK2 is methylated by METTL3 and translated into SIK2-176aa, promoting myoblast growth and muscle hypertrophy, revealing an m6A-dependent circRNA translation mechanism in poultry.
Image credit: pgen.1011934
10/24/2025
research article
TSSKL is essential for sperm mitochondrial morphogenesis and male fertility in moths
Using CRISPR/Cas9 in silk and diamondback moths, the authors show that the testis-specific kinase-like gene TSSKL is essential for male fertility. Loss of TSSKL disrupts mitochondrial structure and metabolism in both sperm types, causing complete male sterility and identifying TSSKL as a potential pest control target.
Image credit: pgen.1011914
10/13/2025
research article
Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics
The authors show that FimX controls type IV pilus extension in Pseudomonas aeruginosa via the ATPase PilB. Deleting fimX shortens pili and impairs twitching, rescued by mutations that enhance PilB activity.
Image credit: pgen.1011802
10/22/2025
research article
C. elegans SAS-1 ensures centriole integrity and ciliary function, and operates with SSNA-1
In this study, the authors show that SAS-1 maintains centriole integrity and ciliary function in C. elegans, acting with SSNA-1 to recruit it to centrioles and microtubules and ensure organelle stability.
Image credit: pgen.1011912
10/15/2025
research article
The intracellular symbiont Wolbachia alters Drosophila development and metabolism to buffer against nutritional stress
Using Drosophila melanogaster and its native Wolbachia strain wMel, the authors show that infection supports development and buffers against nutritional stress.
Image credit: pgen.1011905
10/23/2025
research article
Paf1C regulates the Neurospora circadian clock by promoting the transcription elongation of frequency
In this study, the authors show that Paf1C sustains the Neurospora circadian rhythm by promoting elongation of the clock gene frq through histone modification and H2B ubiquitination.
Image credit: pgen.1011926
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